3118852-74-4
3118852-74-4
Chemical Structure
HDAC6-IN-80
- CAS No.: 3118852-74-4
- Formula:C21H23N3O4
- Molecular Weight:381.43
InChIKey: OJODJUIOIMZIJZ-UHFFFAOYSA-N
SMILES: ONC(CCCCCOC1=CC=C(C2=NC(C3=CC=C(C)C=C3)=NO2)C=C1)=O
Biological Activity: HDAC6-IN-80 is an orally active, selective HDAC6 inhibitor with an IC50 of 8.5 nM. HDAC6-IN-80 inhibits lipopolysaccharide-induced microglial activation, reduces the levels of iNOS, COX-2, TNF-α and IL-6, and alleviates sensory hypersensitivity behaviors. HDAC6-IN-80 can be used for the research of inflammatory pain and chemotherapy-induced peripheral neuropathy[1].
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HDAC6-IN-80 | HDAC6-IN-80 is an orally active, selective HDAC6 inhibitor with an IC50 of 8.5 nM. HDAC6-IN-80 inhibits lipopolysaccharide-induced microglial activation, reduces the levels of iNOS, COX-2, TNF-α and IL-6, and alleviates sensory hypersensitivity behaviors. HDAC6-IN-80 can be used for the research of inflammatory pain and chemotherapy-induced peripheral neuropathy. | |||||||||||||||||||||
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