3119375-08-2
3119375-08-2
Chemical Structure
NT32
- CAS No.: 3119375-08-2
- Formula:C42H64N18O12S
- Molecular Weight:1045.14
InChIKey: ZGHAWWXVDZFBIB-PISZGLHLSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](CSCC(N=N2)=CN2CC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@](C(N[C@H](C(N)=O)CC3=CNC=N3)=O)([C@H](O)C)[H])=O)CCCCN)=O)CCC(O)=O)=O)CCCCN)=O)O[C@H]1N4C=NC5=C(N)N=CN=C54
Biological Activity: NT32 is a selective METTL13 stabilizer with a Kd value of 14 μM. NT32 could occupy both the SAM/SAH-binding pocket and the peptide substrate-binding site of METTL13 simultaneously. NT32 specifically targets and stabilizes METTL13. NT32 shows no inhibitory activity against non-small cell lung cancer[1].
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NT32 | NT32 is a selective METTL13 stabilizer with a Kd value of 14 μM. NT32 could occupy both the SAM/SAH-binding pocket and the peptide substrate-binding site of METTL13 simultaneously. NT32 specifically targets and stabilizes METTL13. NT32 shows no inhibitory activity against non-small cell lung cancer. | |||||||||||||||||||||
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