3123529-62-1
Chemical Structure
PARP1/c-Met-IN-3
- CAS No.: 3123529-62-1
- Formula:C38H28FN9O2
- Molecular Weight:661.69
InChIKey: ZDBGDODRVHENBY-UHFFFAOYSA-N
SMILES: FC1=CC=C(CC2=NNC(C3=C2C=CC=C3)=O)C=C1C(NCC4=CC=C(C5=NC(N(C(C)C6=CC(C=CC=N7)=C7C=C6)N=N8)=C8N=C5)C=C4)=O
Biological Activity: PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC50 of 5.4 nM against c-Met and an IC50 of 3.7 nM against PARP1. PARP1/c-Met-IN-3 inhibits PARP2 enzymatic activity with an IC50 of 4.52 nM, and shows no specificity for PARP1 and PARP2. PARP1/c-Met-IN-3 induces cell cycle arrest and apoptosis. PARP1/c-Met-IN-3 exhibits anti-tumor activity against triple-negative breast cancer[1].
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PARP1/c-Met-IN-3 | PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC50 of 5.4 nM against c-Met and an IC50 of 3.7 nM against PARP1. PARP1/c-Met-IN-3 inhibits PARP2 enzymatic activity with an IC50 of 4.52 nM, and shows no specificity for PARP1 and PARP2. PARP1/c-Met-IN-3 induces cell cycle arrest and apoptosis. PARP1/c-Met-IN-3 exhibits anti-tumor activity against triple-negative breast cancer. | |||||||||||||||||||||
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Keywords
