3135322-96-9
Chemical Structure
ZJCK-6-72
- CAS. Nr.: 3135322-96-9
- Formula:C26H23N5O
- Molecular Weight:421.49
InChIKey: QCFHPNBNZSWNLI-XMMPIXPASA-N
SMILES: CC(C=C1)=NC2=C1C(C3=CC4=C(C=C3)N=CN=C4N5CCO[C@@H](C6=CC=CC=C6)C5)=CN2
Biological Activity: ZJCK-6-72 is a potent, orally effective DYRK1A inhibitor that crosses the blood-brain barrier, with an IC50 of 8.64 nM. ZJCK-6-72 binds to the hinge region of the ATP pocket of DYRK1A and reduces P-gp efflux, thereby blocking the activation of NF-κB and the NLRP3 inflammasome, and significantly downregulating pro-inflammatory cytokines such as TNF-α and IL-6, NO levels, and Pyroptosis. ZJCK-6-72 can be used for research on Alzheimer's disease[1].
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ZJCK-6-72 | ZJCK-6-72 is a potent, orally effective DYRK1A inhibitor that crosses the blood-brain barrier, with an IC50 of 8.64 nM. ZJCK-6-72 binds to the hinge region of the ATP pocket of DYRK1A and reduces P-gp efflux, thereby blocking the activation of NF-κB and the NLRP3 inflammasome, and significantly downregulating pro-inflammatory cytokines such as TNF-α and IL-6, NO levels, and Pyroptosis. ZJCK-6-72 can be used for research on Alzheimer's disease. | |||||||||||||||||||||
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