3137192-95-8
Chemical Structure
MRGPRX4 modulator-3
- CAS No.: 3137192-95-8
- Formula:C19H22FN3S
- Molecular Weight:343.46
IUPAC Name: 4-(4-fluorophenyl)-2-(2-((1S,4S,Z)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene)hydrazinyl)thiazole
InChIKey: FDFPXELRKLOSLT-BANNAZRQSA-N
SMILES: C[C@]1(C2(C)C)/C(C[C@@H]2CC1)=N\NC3=NC(C4=CC=C(F)C=C4)=CS3
Biological Activity: MRGPRX4 modulator-3 (Compound 1C) is a negative allosteric MAS-related G-protein-coupled receptor X4 (MRGPRX4) modulator. MRGPRX4 modulator-3 significantly attenuates Nateglinide (HY-B0422) (orthosteric agonist)-induced responses with an IC50 of 337 nM. MRGPRX4 modulator-3 can be used for chronic itch (especially cholestatic itch) and pain research[1].
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MRGPRX4 modulator-3 | MRGPRX4 modulator-3 (Compound 1C) is a negative allosteric MAS-related G-protein-coupled receptor X4 (MRGPRX4) modulator. MRGPRX4 modulator-3 significantly attenuates Nateglinide (HY-B0422) (orthosteric agonist)-induced responses with an IC50 of 337 nM. MRGPRX4 modulator-3 can be used for chronic itch (especially cholestatic itch) and pain research. | |||||||||||||||||||||
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