3137325-81-3
3137325-81-3
Chemical Structure
DF-CIV-2
- CAS. Nr.: 3137325-81-3
- Formula:C33H29F3N4O3
- Molecular Weight:586.60
InChIKey: JRPYKQGPLVUDPN-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C(C=CC=C2)=C2OC3=CC=C(C=C3)C(F)(F)F)=CC(N4CCN(CC4)C(NC5=CC=CC=C5)=O)=C1)C=C
Biological Activity: DF-CIV-2 is a TEAD2 inhibitor. DF-CIV-2 covalently modifies the TEAD2 palmitoylation pocket, inhibiting TEAD2 palmitoylation and YAP-TEAD binding. DF-CIV-2 inhibits YAP/TAZ-TEAD transcriptional output and downregulates Hippo target genes. DF-CIV-2 can be used for research on malignant mesothelioma[1].
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DF-CIV-2 | DF-CIV-2 is a TEAD2 inhibitor. DF-CIV-2 covalently modifies the TEAD2 palmitoylation pocket, inhibiting TEAD2 palmitoylation and YAP-TEAD binding. DF-CIV-2 inhibits YAP/TAZ-TEAD transcriptional output and downregulates Hippo target genes. DF-CIV-2 can be used for research on malignant mesothelioma. | |||||||||||||||||||||
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