315-80-0
Chemical Structure
Dibenzepine hydrochloride
- CAS No.: 315-80-0
- Formula:C18H22ClN3O
- Molecular Weight:331.84
IUPAC Name: 10-(2-(dimethylamino)ethyl)-5-methyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one hydrochloride
InChIKey: RJPZIQRLRMWPRF-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C3=C(N1CCN(C)C)C=CC=C3)C=CC=C2.Cl
Biological Activity: Dibenzepine hydrochloride is a blood-brain barrier permeable ligand of the histamine H1 receptor (Histamine H1 Receptor), with a Ki value of 0.02 μM. Dibenzepine hydrochloride exhibits varying degrees of affinity for multiple serotonin receptors and dopamine receptors. Dibenzepine hydrochloride can be used in research related to depression, schizophrenia, dementia, and non-specific agitation[1][2][3][4][5][6][7][8][9][10].
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Dibenzepine hydrochloride | Dibenzepine hydrochloride is a blood-brain barrier permeable ligand of the histamine H1 receptor (Histamine H1 Receptor), with a Ki value of 0.02 μM. Dibenzepine hydrochloride exhibits varying degrees of affinity for multiple serotonin receptors and dopamine receptors. Dibenzepine hydrochloride can be used in research related to depression, schizophrenia, dementia, and non-specific agitation. | |||||||||||||||||||||
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References
- [1]. Bieszczad B, et al. Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs. Bioorganic & medicinal chemistry letters. 2020 Nov 01;30(21):127493.
- [2]. Bieszczad B, et al. Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs. Bioorganic & medicinal chemistry letters. 2020 Nov 01;30(21):127493.
- [3]. De Leenheer A, et al. Improved method for determining dibenzepine and its N-demethylated metabolites in human urine. J Pharm Sci. 1973 Jan;62(1):31-6.
- [4]. Brochon R, et al. The detection and determination of dibenzepine and its metabolites in autopsy material. Arch Toxikol. 1969;24(4):249-59.
- [5]. Christensen H, et al. Dibenzepine and its metabolites in blood, muscle, liver, vitreous body and urine from fatal poisoning. Acta Pharmacol Toxicol (Copenh). 1975 Nov;37(5):393-401.
- [6]. Bonnichsen R, et al. Determination of dibenzepine in autopsy material. Z Rechtsmed. 1971;68(5):253-60.
- [7]. Schlicht HJ, et al. Gas chromatographic determination of dibenzepine and its basic metabolites in biological material. J Chromatogr. 1978 Dec 11;166(2):599-603.
- [8]. Langslet A, et al. Effects of dibenzepine and imipramine on the isolated rat heart. Eur J Pharmacol. 1971 May;14(4):333-9. [Content Brief]
- [9]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]
- [10]. Jadrić R, et al. Comparison of trazodone, diazepame and dibenzepine influences on rat brain beta-endorphins content. Bosnian journal of basic medical sciences. 2007 Aug;7(3):222-5.
