316371-83-2
Chemical Structure
Rosiglitazone sodium
Synonym(s): BRL 49653 sodium
- CAS No.: 316371-83-2
- Formula:C18H18N3NaO3S
- Molecular Weight:379.41
IUPAC Name: sodium 5-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)benzyl)-2,4-dioxothiazolidin-3-ide
InChIKey: XFOHHIYSRDUSCX-UHFFFAOYSA-M
SMILES: O=C([N-]1)SC(CC2=CC=C(OCCN(C)C3=NC=CC=C3)C=C2)C1=O.[Na+]
Biological Activity: Rosiglitazone sodium is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone sodium is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
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Rosiglitazone sodium | Rosiglitazone sodium is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone sodium is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5). | |||||||||||||||||||||
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Keywords
