3187-52-8
Chemical Structure
Variabilin
Synonym(s): Homopisatin
- CAS No.: 3187-52-8
- Formula:C17H16O5
- Molecular Weight:300.31
InChIKey: VVPGAJNPGZZNBM-SJORKVTESA-N
SMILES: O[C@@]12[C@@](OC3=CC(OC)=CC=C32)([H])C4=CC=C(OC)C=C4OC1
Biological Activity: Variabilin (Homopisatin) is a potent RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Variabilin potently inhibits platelet aggregation induced by the platelet agonists ADP, collagen, and thrombin receptor peptide SFLLRNP. Variabilin also blocks platelet adhesion to immobilized Fg. In addition, Variabilin inhibits binding of purified human GPIIb-IIIa to immobilized Fg[1][2].
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Variabilin | Variabilin (Homopisatin) is a potent RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Variabilin potently inhibits platelet aggregation induced by the platelet agonists ADP, collagen, and thrombin receptor peptide SFLLRNP. Variabilin also blocks platelet adhesion to immobilized Fg. In addition, Variabilin inhibits binding of purified human GPIIb-IIIa to immobilized Fg. | |||||||||||||||||||||
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- [1]. Wang X, et al. Variabilin, a novel RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. J Biol Chem. 1996 Jul 26;271(30):17785-90. [Content Brief]
- [2]. Kurosawa K, et al. Variabilin, a 6a-hydroxypterocarpan from Dalbergia variabilis[J]. Phytochemistry, 1978, 17(8): 1417-1418.
Keywords
