318967-58-7
318967-58-7
Chemical Structure
APC0576
- CAS No.: 318967-58-7
- Formula:C23H27N3O3
- Molecular Weight:393.48
IUPAC Name: (S)-N-(6-(4-((S)-2,2-dimethylcyclopropane-1-carboxamido)phenoxy)pyridin-3-yl)-2,2-dimethylcyclopropane-1-carboxamide
InChIKey: GABIPKHJFWRJQJ-QZTJIDSGSA-N
SMILES: O=C([C@@H]1C(C)(C1)C)NC(C=N2)=CC=C2OC(C=C3)=CC=C3NC([C@@H]4C(C)(C4)C)=O
Biological Activity: APC0576 is an inhibitor for the activation of NF-κB signaling pathway, and inhibits the activation of NF-κB depedent gene (IC50 is 1.0 μM for β-gal). APC0576 inhibits IL-1-induced chemokines release, and can be used in research about pathological endothelial cell activation releted diseases[1].
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APC0576 | APC0576 is an inhibitor for the activation of NF-κB signaling pathway, and inhibits the activation of NF-κB depedent gene (IC50 is 1.0 μM for β-gal). APC0576 inhibits IL-1-induced chemokines release, and can be used in research about pathological endothelial cell activation releted diseases. | |||||||||||||||||||||
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