320347-28-2
Chemical Structure
PAR3 (1-6) (human)
Synonym(s): TFRGAP
- CAS No.: 320347-28-2
- Formula:C29H45N9O8
- Molecular Weight:647.72
InChIKey: LGNVPMUJJJLQHG-WZZXNIEWSA-N
SMILES: O=C(N(CCC1)[C@@H]1C(O)=O)[C@H](C)NC(CNC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC2=CC=CC=C2)=O)=O)=O
Biological Activity: PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.
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PAR3 (1-6) (human) | PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110. | |||||||||||||||||||||
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Keywords
