324561-95-7
Chemical Structure
IS20
- CAS No.: 324561-95-7
- Formula:C23H21N3O3
- Molecular Weight:387.43
IUPAC Name: (E)-N-(1-(4-methoxyphenyl)-3-oxo-3-((pyridin-3-ylmethyl)amino)prop-1-en-2-yl)benzamide
InChIKey: KKDANILRTKQMGA-KGENOOAVSA-N
SMILES: O=C(C1=CC=CC=C1)N/C(C(NCC2=CC=CN=C2)=O)=C/C3=CC=C(C=C3)OC
Biological Activity: IS20 is a Prokineticin receptor 1 (PKR1) agonist. IS20 diminishes Doxorubicin (HY-15142A) mediated apoptosis and ROS production by activating Akt or MAPK pathways. IS20 protects the heart against Doxorubicin-induced cardiovascular toxicity and improves the survival rate and cardiac function in mouse models. IS20 does not alter the cytotoxicity and antitumor activity of acute DOX treatment in breast cancer cells and MDA-MB-231 xenograft mouse models. IS20 can be used for cancers research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IS20 | 99.85% | IS20 is a Prokineticin receptor 1 (PKR1) agonist. IS20 diminishes Doxorubicin (HY-15142A) mediated apoptosis and ROS production by activating Akt or MAPK pathways. IS20 protects the heart against Doxorubicin-induced cardiovascular toxicity and improves the survival rate and cardiac function in mouse models. IS20 does not alter the cytotoxicity and antitumor activity of acute DOX treatment in breast cancer cells and MDA-MB-231 xenograft mouse models. IS20 can be used for cancers research. | ||||||||||||||||||||
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Keywords
