32462-30-9
Chemical Structure
Oxfenicine
Synonym(s): L-p-Hydroxyphenylglycine; 4-Hydroxy-L-phenylglycine; UK 25842
- CAS No.: 32462-30-9
- Formula:C8H9NO3
- Molecular Weight:167.16
IUPAC Name: (S)-2-amino-2-(4-hydroxyphenyl)acetic acid
InChIKey: LJCWONGJFPCTTL-ZETCQYMHSA-N
SMILES: O=C([C@H](C1=CC=C(C=C1)O)N)O
Biological Activity: Oxfenicine (L-p-Hydroxyphenylglycine) is an orally active carnitine palmitoyltransferase-1 inhibitor. Oxfenicine inhibits the oxidation of fatty acids in the heart, protecting cardiac tissue from necrotic damage during ischemia, and also has an inhibitory effect on cardiac tissue apoptosis. In addition, Oxfenicine promotes lipolysis in a high-fat diet rat model. Oxfenicine can be used in the study of cardiovascular and metabolic diseases[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Oxfenicine | 99.98% | Oxfenicine (L-p-Hydroxyphenylglycine) is an orally active carnitine palmitoyltransferase-1 inhibitor. Oxfenicine inhibits the oxidation of fatty acids in the heart, protecting cardiac tissue from necrotic damage during ischemia, and also has an inhibitory effect on cardiac tissue apoptosis. In addition, Oxfenicine promotes lipolysis in a high-fat diet rat model. Oxfenicine can be used in the study of cardiovascular and metabolic diseases. | ||||||||||||||||||||
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2-(4-Hydroxyphenyl)-L-glycine-d2 | 2-(4-Hydroxyphenyl)-L-glycine-d2 is the deuterium labeled 2-(4-Hydroxyphenyl)-L-glycine. | |||||||||||||||||||||
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- [1]. Stephens TW, et, al. Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine. Biochem J. 1985 Apr 15;227(2):651-60. [Content Brief]
- [2]. Greaves P, et, al. Cardiac hypertrophy in the dog and rat induced by oxfenicine, an agent which modifies muscle metabolism. Arch Toxicol Suppl. 1984;7:488-93. [Content Brief]
- [3]. Kennedy JA, et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. J Cardiovasc Pharmacol. 2000 Dec;36(6):794-801. [Content Brief]
- [4]. Sepa-Kishi DM, et al. Antilipolytic and antilipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats. Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311(4):R779-R787. [Content Brief]
- [5]. Kong JY, et al. Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin. Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H717-25. [Content Brief]
