328069-91-6
328069-91-6
Chemical Structure
MT477
- CAS No.: 328069-91-6
- Formula:C31H30N2O12S3
- Molecular Weight:718.77
IUPAC Name: tetramethyl 6-(2-(2,5-dioxopyrrolidin-1-yl)acetyl)-7-methoxy-5,5-dimethyl-5,6-dihydrospiro[thiopyrano[2,3-c]quinoline-1,2'-[1,3]dithiole]-2,3,4',5'-tetracarboxylate
InChIKey: AQFSTZWCFIWEMA-UHFFFAOYSA-N
SMILES: O=C(OC)C1=C(SC2=C(C3=C(C(OC)=CC=C3)N(C2(C)C)C(CN4C(CCC4=O)=O)=O)C15SC(C(OC)=O)=C(S5)C(OC)=O)C(OC)=O
Biological Activity: MT477 is a potent protein kinase C (PKC) inhibitor. MT477 induces apoptosis and necrosis. MT477 decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1. MT477 shows antitumor activity[1].
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MT477 | MT477 is a potent protein kinase C (PKC) inhibitor. MT477 induces apoptosis and necrosis. MT477 decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1. MT477 shows antitumor activity. | |||||||||||||||||||||
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