MT477
MT477 is a potent protein kinase C (PKC) inhibitor. MT477 induces apoptosis and necrosis. MT477 decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1. MT477 shows antitumor activity.
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- CAS No.: 328069-91-6
- Formule: C31H30N2O12S3
- Masse moléculaire:718.77
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MT477 (0.05 mM; 1, 24 h) induces apoptosis and necrosis in a time-dependent manner[1].
MT477 (0.05 mM; 0.5, 1, 2, 4 h) decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1 in a time-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, U87, H226, LNCaP, A549, A431 cells
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Concentration:0.001-1 mM
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Incubation Time:1 h
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Result:Showed antiproliferative activity with IC50s of 0.018, 0.051, 0.013, 0.033, 0.020, 0.049 mM for MCF-7, U87, H226, LNCaP, A549, A431 cells, respectively.
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Cell Line:H266 cells
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Concentration:0.05 mM
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Incubation Time:0.5, 1, 2, 4 h
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Result:Decreased the protein expression of Ras-GTP, p-Erk1/2, p-Elk1 in a time-dependent manner.
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Cell Line:H266 cells
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Concentration:0.05 mM
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Incubation Time:1, 24 h
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Result:Induced apoptosia with the percentage of cells underwent apoptosis after 1 h of treatment of 18.6 and after 24 h of treatment of 98%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old male nude mice (A431 cells) [1]
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Dosage:33, 100, 1000 µg/kg
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Administration:I.p.; once a day on days 1, 4, 8, 16, 18, 20
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Result:Significant decreased in tumor volume of 24.5% by the third week at 1 mg/kg.
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Animal Model:6-week-old male nude mice (H226 cells) [1]
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Dosage:1 mg/kg
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Administration:I.p.; once a day on days 1, 4, 8, 20, 24, 28
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Result:Inhibited tumor growth by 43.6% and observed no weight loss.
Chemical Information
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CAS No. 328069-91-6
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Masse moléculaire 718.77
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Formule C31H30N2O12S3
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SMILES
O=C(OC)C1=C(SC2=C(C3=C(C(OC)=CC=C3)N(C2(C)C)C(CN4C(CCC4=O)=O)=O)C15SC(C(OC)=O)=C(S5)C(OC)=O)C(OC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MT477 Related Classifications
HY-122241 Related Classifications
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