33211-22-2
Chemical Structure
Vicanicin
- CAS No.: 33211-22-2
- Formula:C18H16Cl2O5
- Molecular Weight:383.22
InChIKey: DJIUVCGPONSSSV-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C(C)=C(C(OC)=C2C)Cl)OC3=C1C(C)=C(C(O)=C3C)Cl
Biological Activity: Vicanicin is a depsidone compound found in lichens. Vicanicin inhibits the expression of Hsp70, regulates the redox-sensitive mechanisms within cells, promotes the increase of reactive oxygen species (ROS) in cancer cells, changes the Bax/Bcl-2 ratio, activates caspase-3, and triggers apoptosis. Vicanicin inhibits cell growth and induces apoptosis in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. Vicanicin is promising for research of prostate cancer[1].
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Vicanicin | Vicanicin is a depsidone compound found in lichens. Vicanicin inhibits the expression of Hsp70, regulates the redox-sensitive mechanisms within cells, promotes the increase of reactive oxygen species (ROS) in cancer cells, changes the Bax/Bcl-2 ratio, activates caspase-3, and triggers apoptosis. Vicanicin inhibits cell growth and induces apoptosis in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. Vicanicin is promising for research of prostate cancer. | |||||||||||||||||||||
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Keywords
