333409-31-7
333409-31-7
Chemical Structure
5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione
- CAS. Nr.: 333409-31-7
- Formula:C7H8N4O2S2
- Molecular Weight:244.29
IUPAC Name: 5,5'-(propane-1,3-diyl)bis(1,3,4-oxadiazole-2(3H)-thione)
InChIKey: XQFRUIPQODDPMN-UHFFFAOYSA-N
SMILES: S=C1OC(CCCC2=NNC(O2)=S)=NN1
Biological Activity: 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC50 of 429 and 467 μM. 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione inhibits mushroom tyrosinase weakly, with Ki of 1.9 μM[1][2].
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5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione | 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC50 of 429 and 467 μM. 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione inhibits mushroom tyrosinase weakly, with Ki of 1.9 μM. | |||||||||||||||||||||
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References
- [1]. Khan KM, et al., 1,3,4-Oxadiazole-2(3H)-thione and its analogues: a new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors. Bioorg Med Chem. 2009 Nov 15;17(22):7816-22. [Content Brief]
- [2]. Ghani U, et al., New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site. Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. [Content Brief]
