336884-84-5
Chemical Structure
R116031
- CAS No.: 336884-84-5
- Formula:C35H38F6N4O2
- Molecular Weight:660.69
IUPAC Name: 2-(4-((2R,4S)-2-benzyl-1-(3,5-bis(trifluoromethyl)benzoyl)piperidin-4-yl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide
InChIKey: KHOXGPDKCIQOOR-XZWHSSHBSA-N
SMILES: O=C(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N2[C@@H](C[C@@H](N3CCN(CC3)CC(NC4=C(C=CC=C4C)C)=O)CC2)CC5=CC=CC=C5
Biological Activity: R116031 is a selective Neurokinin-1 (NK-1) receptor antagonist with a Ki of 0.45 nM for human NK-1 receptor. R116031 inhibits Substance P (HY-P0201)-induced peripheral effects (skin reactions and plasma extravasation in guinea pigs) and a central effect (thumping in gerbils).R116031 labeled with 3H significantly accumulate in the striatum, olfactory tubercule, olfactory bulb and locus coeruleus in gerbils models. R116031 can be used as a positron emission tomography (PET) ligand for PET imaging[1].
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R116031 | R116031 is a selective Neurokinin-1 (NK-1) receptor antagonist with a Ki of 0.45 nM for human NK-1 receptor. R116031 inhibits Substance P (HY-P0201)-induced peripheral effects (skin reactions and plasma extravasation in guinea pigs) and a central effect (thumping in gerbils).R116031 labeled with 3H significantly accumulate in the striatum, olfactory tubercule, olfactory bulb and locus coeruleus in gerbils models. R116031 can be used as a positron emission tomography (PET) ligand for PET imaging. | |||||||||||||||||||||
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Keywords
