3443-45-6
Chemical Structure
1-Pyrenebutyric acid
- CAS No.: 3443-45-6
- Formula:C20H16O2
- Molecular Weight:288.35
IUPAC Name: 4-(pyren-1-yl)butanoic acid
InChIKey: QXYRRCOJHNZVDJ-UHFFFAOYSA-N
SMILES: C1=CC2=C3C(=C1)C=CC4=C(CCCC(=O)O)C=CC(=C43)C=C2
Biological Activity: 1-Pyrenebutyric acid is a pyrene-based fluorescent probe compound. The fluorescence lifetime of 1-Pyrenebutyric acid is quenched by molecular oxygen and intracellular ROS, thus it serves as a fluorescent probe for detecting ROS and oxygen concentration through fluorescence lifetime measurements. 1-Pyrenebutyric acid undergoes electrostatic interactions with arginine-rich peptides, increasing their net hydrophobicity, promoting their direct translocation across lipid bilayers, and enhancing cytosolic delivery. 1-Pyrenebutyric acid is used for intracellular reactive oxygen species detection and research related to arginine-rich peptide-mediated cytosolic delivery[1][2].
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1-Pyrenebutyric acid | 97.61% | 1-Pyrenebutyric acid is a pyrene-based fluorescent probe compound. The fluorescence lifetime of 1-Pyrenebutyric acid is quenched by molecular oxygen and intracellular ROS, thus it serves as a fluorescent probe for detecting ROS and oxygen concentration through fluorescence lifetime measurements. 1-Pyrenebutyric acid undergoes electrostatic interactions with arginine-rich peptides, increasing their net hydrophobicity, promoting their direct translocation across lipid bilayers, and enhancing cytosolic delivery. 1-Pyrenebutyric acid is used for intracellular reactive oxygen species detection and research related to arginine-rich peptide-mediated cytosolic delivery. | ||||||||||||||||||||
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References
- [1]. Takeuchi T, et al. Direct and rapid cytosolic delivery using cell-penetrating peptides mediated by pyrenebutyrate. ACS chemical biology. 2006 Jun 20;1(5):299-303.
- [2]. Rharass T, et al. Variation of 1-pyrenebutyric acid fluorescence lifetime in single living cells treated with molecules increasing or decreasing reactive oxygen species levels. Analytical biochemistry. 2006 Oct 01;357(1):1-8. [Content Brief]
