34783-48-7
34783-48-7
Chemical Structure
PF-04859989
- CAS No.: 34783-48-7
- Formula:C9H10N2O2
- Molecular Weight:178.19
IUPAC Name: (S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one
InChIKey: HYTRYTZFJVVZAF-ZETCQYMHSA-N
SMILES: O=C1N(O)C2=C(C=CC=C2)C[C@@H]1N
Biological Activity: PF-04859989 is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively)[1].
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PF-04859989 | PF-04859989 is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively). | |||||||||||||||||||||
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References
Keywords
