34966-41-1
Chemical Structure
Cartazolate
Synonym(s): SQ 65396
- CAS No.: 34966-41-1
- Formula:C15H22N4O2
- Molecular Weight:290.36
InChIKey: IQNQAOGGWGCROX-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C2C(C=NN2CC)=C1NCCCC)OCC
Biological Activity: Cartazolate (SQ 65396) is a pyrazolopyridine modulator with benzodiazepine receptor agonist activity and cyclic AMP phosphodiesterase inhibitory activity. Cartazolate enhances the affinity of 3H-diazepam for brain-specific binding sites, regulates the GABA/benzodiazepine receptor complex, reversibly increases Na+-independent GABA receptor binding sites, and stimulates the binding of [3H]flunitrazepam to cerebellar membranes. Cartazolate restores punishment-suppressed behavior and exhibits anxiolytic properties. Cartazolate is applicable to anxiety-related research[1][2][3].
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Cartazolate | Cartazolate (SQ 65396) is a pyrazolopyridine modulator with benzodiazepine receptor agonist activity and cyclic AMP phosphodiesterase inhibitory activity. Cartazolate enhances the affinity of 3H-diazepam for brain-specific binding sites, regulates the GABA/benzodiazepine receptor complex, reversibly increases Na+-independent GABA receptor binding sites, and stimulates the binding of [3H]flunitrazepam to cerebellar membranes. Cartazolate restores punishment-suppressed behavior and exhibits anxiolytic properties. Cartazolate is applicable to anxiety-related research. | |||||||||||||||||||||
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References
- [1]. Beer B, et al. Enhancement of 3H-diazepam binding by SQ 65,396: a novel anti-anxiety agent. Pharmacology, biochemistry, and behavior. 1978 Dec;9(6):849-51. [Content Brief]
- [2]. Placheta P, et al. In vitro modulation by SQ 20009 and SQ 65396 of GABA receptor binding in rat CNS membranes. European journal of pharmacology. 1980 Mar 21;62(2-3):225-8. [Content Brief]
- [3]. Supavilai P, et al. Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the gaba/benzodiazepine receptor complex of the cerebellum. European journal of pharmacology. 1981 Mar 12;70(2):183-93. [Content Brief]
