Enhancement of 3H-diazepam binding by SQ 65,396: a novel anti-anxiety agent

  • Pharmacol Biochem Behav. 1978 Dec;9(6):849-51. doi: 10.1016/0091-3057(78)90367-2.
B Beer ,  C A Klepner ,  A S Lippa ,  R F Squires
PMID: 34174 DOI: 10.1016/0091-3057(78)90367-2
Abstract

SQ 65,396, a clinically active anti-anxiety agent, enhanced the binding of 3H-diazepam at 1.5 nM. This effect was due to an increase in the affinity for the ligand, without a change in the number of 3H-diazepam binding sites. This action of SQ 65,396 may mediate its anti-anxiety effects by affecting the action of an endogenous modulator of the "benzodiazepine receptor." Several Other substances and treatments increase the affinity of 3H-diazepam for its receptors by mechanisms which may be related to the effect produced by SQ 65,396.

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