352438-73-4
352438-73-4
Chemical Structure
5-Hydroxymethyluracil-d3
- CAS No.: 352438-73-4
- Formula:C5H3D3N2O3
- Molecular Weight:145.13
IUPAC Name: 5-(hydroxymethyl-d2)pyrimidine-2,4(1H,3H)-dione-6-d
InChIKey: JDBGXEHEIRGOBU-APAIHEESSA-N
SMILES: OC([2H])([2H])C(C(N1)=O)=C([2H])NC1=O
Biological Activity: 5-Hydroxymethyluracil-d3 is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].
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5-Hydroxymethyluracil-d3 | 99% | 5-Hydroxymethyluracil-d3 is the deuterium labeled 5-Hydroxymethyluracil. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase. | ||||||||||||||||||||
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5-Hydroxymethyluracil (Standard) | ≥98% | 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase. | ||||||||||||||||||||
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5-Hydroxymethyluracil | 99.85% | 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Djuric Z, et al. Quantitation of 5-(hydroxymethyl)uracil in DNA by gas chromatography with mass spectral detection. Chem Res Toxicol. 1991 Nov-Dec;4(6):687-91. [Content Brief]
- [3]. Janoušková M, et al. 5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chem Commun (Camb). 2017 Dec 12;53(99):13253-13255. [Content Brief]
