35874-49-8
Chemical Structure
8-NH2-ATP
Synonym(s): 8-Aminoadenosine-5'-O-triphosphate
- CAS 番号: 35874-49-8
- Formula:C10H17N6O13P3
- Molecular Weight:522.20
IUPAC Name: ((2R,3S,4R,5R)-5-(6,8-diamino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: FRQGDEVDOCHMCQ-UUOKFMHZSA-N
SMILES: NC(N([C@]([C@@H]([C@@H]1O)O)([H])O[C@@H]1CO[P](O[P](O[P](O)(O)=O)(O)=O)(O)=O)C2=NC=N3)=NC2=C3N
Biological Activity: 8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase[1][2].
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8-NH2-ATP | 8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase. | |||||||||||||||||||||
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- [1]. Nancy L Krett, et al. 8-amino-adenosine is a potential therapeutic agent for multiple myeloma. Mol Cancer Ther. 2004 Nov;3(11):1411-20. [Content Brief]
- [2]. Yuji Matsuzaki, et al. ATP-association to intrabacterial nanotransportation system in Vibrio cholera. Med Mol Morphol. 2015 Dec;48(4):225-34. [Content Brief]
Keywords