3600-95-1
3600-95-1
Chemical Structure
Perezone
- CAS No.: 3600-95-1
- Formula:C15H20O3
- Molecular Weight:248.32
SMILES: C/C(C)=C\CC[C@H](C1=C(C(C(C)=CC1=O)=O)O)C
Biological Activity: Perezone is a sesquiterpenoid benzoquinone found in the roots of Acourtia species. Perezone inhibits the activity of leukemia cell line K-562 and human glioma cell line U-251 (IC50: 6.83 μM). Perezone increases the expression of caspase 3, 8, and 9 genes associated with apoptosis. Perezone has antioxidant and anti-inflammatory activities[1][2][3][4][5].
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Perezone | Perezone is a sesquiterpenoid benzoquinone found in the roots of Acourtia species. Perezone inhibits the activity of leukemia cell line K-562 and human glioma cell line U-251 (IC50: 6.83 μM). Perezone increases the expression of caspase 3, 8, and 9 genes associated with apoptosis. Perezone has antioxidant and anti-inflammatory activities. | |||||||||||||||||||||
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References
- [1]. Gómez-Serrano G, et al. Time-dependent perezone production in different culture systems of Acourtia cordata[J]. Central European Journal of Biology, 2012, 7: 507-518.
- [2]. Escobedo-González R G, et al. Characterization and comparison of perezone with some analogues. Experimental and theoretical study[J]. Journal of Molecular Structure, 2015, 1097: 98-105.
- [3]. Estévez-Carmona MM, et al. Perezone and its phenyl glycine derivative induce cytotoxicity via caspases on human glial cancer cells. Nat Prod Res. 2024 Jun;38(11):1823-1833. [Content Brief]
- [4]. Concepción Lozada M, et al. Synthesis, cytotoxic and antioxidant evaluations of amino derivatives from perezone. Bioorg Med Chem. 2012 Sep 1;20(17):5077-84. [Content Brief]
- [5]. Martínez J, et al. Computational Characterization of Perezone, Isoperezone and their Sulfur‐Derivatives: Anti‐inflammatory Activity[J]. ChemistrySelect, 2019, 4(45): 13333-13346.
Keywords
