362-29-8
Chemical Structure
Propiomazine
- CAS No.: 362-29-8
- Formula:C20H24N2OS
- Molecular Weight:340.48
IUPAC Name: 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)propan-1-one
InChIKey: UVOIBTBFPOZKGP-UHFFFAOYSA-N
SMILES: CCC(C(C=C1N2CC(N(C)C)C)=CC=C1SC3=C2C=CC=C3)=O
Biological Activity: Propiomazine is an orally active antihistamine agent. Propiomazine is a potent prolactin (PRL) release stimulant, whose effect depends on the antagonism of the dopaminergic system and can inhibit the secretion of luteinizing hormone (LH). Propiomazine is mainly used for anesthesia assistance, mental disorders and anxiety-induced sedation, and can also be used in research related to insomnia[1][2][3][4].
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Propiomazine | 98.91% | Propiomazine is an orally active antihistamine agent. Propiomazine is a potent prolactin (PRL) release stimulant, whose effect depends on the antagonism of the dopaminergic system and can inhibit the secretion of luteinizing hormone (LH). Propiomazine is mainly used for anesthesia assistance, mental disorders and anxiety-induced sedation, and can also be used in research related to insomnia. | ||||||||||||||||||||
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- [1]. B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57(4):239-42. [Content Brief]
- [2]. Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037. [Content Brief]
- [3]. C.Bjerre, et al. Bioavailability of the sedative propiomazine after nasal administration in rats. International Journal of Pharmaceutics, 1996, 144 (2), 217-224.
- [4]. Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178(4):606-9. [Content Brief]
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