36404-88-3
36404-88-3
Chemical Structure
2-Chloronicotinaldehyde
- CAS No.: 36404-88-3
- Formula:C6H4ClNO
- Molecular Weight:141.56
IUPAC Name: 2-chloronicotinaldehyde
InChIKey: KHPAGGHFIDLUMB-UHFFFAOYSA-N
SMILES: O=CC1=CC=CN=C1Cl
Biological Activity: 2-Chloronicotinaldehyde is a starting material and a key intermediate of pharmacophore core scaffolds, and it can be used in life science-related research[1][2][3][4][5].
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2-Chloronicotinaldehyde | 99.76% | 2-Chloronicotinaldehyde is a starting material and a key intermediate of pharmacophore core scaffolds, and it can be used in life science-related research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.86
HY-W0103092-Chloroisonicotinaldehyde -
Similarity Score 0.85
HY-758132-Aminonicotinaldehyde -
Similarity Score 0.80
HY-W0172492-Chloronicotinic acid -
Similarity Score 0.79
HY-W0125912,3-Dichloropyridine -
Similarity Score 0.79
HY-327513-Bromo-2-chlorolpyridine -
Similarity Score 0.79
HY-327532-Chloro-3-iodopyridine -
Similarity Score 0.79
HY-Y02442-Chloropyridin-3-amine -
Similarity Score 0.79
HY-328332-Chloro-3-pyridinol -
Similarity Score 0.78
HY-Y18633-Chlorobenzaldehyde -
Explore the MedChemAI to find more analogs
References
- [1]. Jeong JW, et al. Rhodamine-chloronicotinaldehyde-based "OFF–ON" chemosensor for the colorimetric and fluorescent determination of Al3+ ions. Sens Actuators B Chem. 2015;208:75-84.
- [2]. Suman P, et al. Anti-mycobacterial, cytotoxic activities of Knoevenagel and (E)-α,β-unsaturated esters and ketones from 2-chloronicotinaldehydes. Med Chem Res. 2014;23(1):199-206.
- [3]. Pasha AR, et al. Synthesis, in vitro α-glucosidase inhibitory potential and in silico study of 2-chloro pyridine incorporated thiosemicarbazones. J Mol Struct. 2024;1317:139089.
- [4]. Zhang Y, et al. Substituent-directed reduction of cyclic aminals leading to two different heterocycles selectively: syntheses of functionalized nicotines and pyrido[2,3-b]azepines. Tetrahedron. 2015;71(13):1930-9.
- [5]. Jeong JW, et al. An 'OFF–ON' fluorescent chemosensor based on rhodamine 6G-2-chloronicotinaldehyde for the detection of Al3+ ions: Part II. Sens Actuators B Chem. 2016;227:227-41.
