36413-91-9
Chemical Structure
Geiparvarin
- CAS No.: 36413-91-9
- Formula:C19H18O5
- Molecular Weight:326.34
InChIKey: OUTLLBZGJYDUQE-XYOKQWHBSA-N
SMILES: C/C(C(OC(C)1C)=CC1=O)=C\COC2=CC=C(C=CC(O3)=O)C3=C2
Biological Activity: Geiparvarin is an anticancer agent and an inhibitor of MAO-B (pIC50 = 6.84 μM). Geiparvarin exerts anti-tumor effects by downregulating COX2 expression and inhibiting angiogenesis. Geiparvarin blocks the cell cycle at the G1 phase and induces apoptosis of cancer cells. Geiparvarin has anti-microtubule activity and destroys the cytoskeleton to exert anti-proliferative effects. Geiparvarin has research significance for lung cancer, leukemia, and breast cancer[1][2][3][4][5].
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Geiparvarin | Geiparvarin is an anticancer agent and an inhibitor of MAO-B (pIC50 = 6.84 μM). Geiparvarin exerts anti-tumor effects by downregulating COX2 expression and inhibiting angiogenesis. Geiparvarin blocks the cell cycle at the G1 phase and induces apoptosis of cancer cells. Geiparvarin has anti-microtubule activity and destroys the cytoskeleton to exert anti-proliferative effects. Geiparvarin has research significance for lung cancer, leukemia, and breast cancer. | |||||||||||||||||||||
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References
- [1]. Giampietro Viola, et al. Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues. Chem Biodivers. 2004 Sep;1(9):1265-80. [Content Brief]
- [2]. Bin Wang, et al. Geiparvarin Inhibits the Progression of Osteosarcoma by Down-regulating COX2 Expression. Chem Biodivers. 2004 Sep;1(9):1265-80. [Content Brief]
- [3]. C Bocca, et al. Cytoskeleton-interacting activity of geiparvarin, diethylstilbestrol and conjugates. Chem Biol Interact. 2001 Sep 28;137(3):285-305. [Content Brief]
- [4]. Angelo Carotti, et al. Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3551-5. [Content Brief]
- [5]. Yikai Zhang, et al. Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. Eur J Med Chem. 2012 Jul:53:356-63. [Content Brief]
