366487-89-0
Chemical Structure
AD-2646
Synonym(s): LCL102
- CAS No.: 366487-89-0
- Formula:C23H40N2O4
- Molecular Weight:408.57
IUPAC Name: (1R,2R)-1-(4-nitrophenyl)-2-(tetradecylamino)propane-1,3-diol
InChIKey: SJHLKUDCBZZUEE-DHIUTWEWSA-N
SMILES: O[C@H](C1=CC=C([N+]([O-])=O)C=C1)[C@H](NCCCCCCCCCCCCCC)CO
Biological Activity: AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism[1][2].
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AD-2646 | AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism. | |||||||||||||||||||||
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- [1]. Granot T, et al. Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs. Leukemia. 2006 Mar;20(3):392-9. [Content Brief]
- [2]. Fumiaki Tanaka, et al. In Vivo and In Vitro Inhibition of Human Cancer Cell Growth Using Adenoviral Vector Expressing FHIT Gene: Mechanism Analysis Using Microarray. Volume 7, Issue 5, Supplement S418-S419. May 2003.
Keywords
