AD-2646
Based on 1 publication(s) in Google Scholar
AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism.
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- CAS No.: 366487-89-0
- Formula: C23H40N2O4
- Molecular Weight:408.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) AD-2646
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Biological Activity
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Caspase-8 |
Caspase-9 |
Caspase 3 |
Chemical Information
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CAS No. 366487-89-0
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Molecular Weight 408.57
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Formula C23H40N2O4
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SMILES
O[C@H](C1=CC=C([N+]([O-])=O)C=C1)[C@H](NCCCCCCCCCCCCCC)CO
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Synonyms
LCL102
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Antioxid Redox Signal
Nimodipine Blocks Histone-Induced Calcium Overload to Protect Neurons after Traumatic Brain Injury. [Abstract]2025 Sep 17. PMID: 40960921
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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