36889-15-3
Chemical Structure
Gentamicin B
Synonym(s): SCH-14342
- CAS No.: 36889-15-3
- Formula:C19H38N4O10
- Molecular Weight:482.53
IUPAC Name: (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: RHRAMPXHWHSKQB-GGEUKFTFSA-N
SMILES: O[C@H]([C@H]([C@@H](C[C@@H]1N)N)O[C@@H]2[C@@H]([C@H]([C@@](O)(CO2)C)NC)O)[C@@H]1O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CN
Biological Activity: Gentamicin B (SCH-14342) is a pseudotrisaccharide aminoglycoside antibiotic produced by Micromonospora echinospora. Gentamicin B exhibits antibacterial activity against a variety of Gram-positive and Gram-negative bacteria. Gentamicin B can be used for research on bacterial infections[1][2][3][4].
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Gentamicin B | 99.79% | Gentamicin B (SCH-14342) is a pseudotrisaccharide aminoglycoside antibiotic produced by Micromonospora echinospora. Gentamicin B exhibits antibacterial activity against a variety of Gram-positive and Gram-negative bacteria. Gentamicin B can be used for research on bacterial infections. | ||||||||||||||||||||
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References
- [1]. Thornsberry C, et al. Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin. Antimicrobial agents and chemotherapy. 1980 Aug;18(2):338-45.
- [2]. Waitz JA, et al. Biological activity of Sch 14342, an aminoglycoside antibiotic coproduced in the gentamicin fermentation. Antimicrobial agents and chemotherapy. 1972 Dec;2(6):464-9. [Content Brief]
- [3]. Ban YH, et al. Complete reconstitution of the diverse pathways of gentamicin B biosynthesis. Nature chemical biology. 2019 Mar;15(3):295-303.
- [4]. Wu Z, et al. Improving gentamicin B and gentamicin C1a production by engineering the glycosyltransferases that transfer primary metabolites into secondary metabolites biosynthesis. Microbiological research. 2017 Oct;203:40-46.
