36981-91-6
Chemical Structure
Fepradinol
- CAS No.: 36981-91-6
- Formula:C12H19NO2
- Molecular Weight:209.28
IUPAC Name: 2-((2-hydroxy-2-phenylethyl)amino)-2-methylpropan-1-ol
InChIKey: PVOOBRUZWPQOER-UHFFFAOYSA-N
SMILES: OC(CNC(C)(C)CO)C1=CC=CC=C1
Biological Activity: Fepradinol is an orally active nonsteroidal anti-inflammatory agent. Fepradinol inhibits the increase in vascular permeability induced by histamine, 5-hydroxytryptamine, and bradykinin, reduces exudate volume, prevents leukocyte migration, and suppresses acute inflammation models. Fepradinol also induces thrombotic vasculopathy with epidermal necrosis, without leukocytoclastic vasculitis; triggers occlusive contact dermatitis presenting as purpuric papulonecrotic lesions, and causes strongly positive patch test reactions. Fepradinol can be used in research related to occlusive contact dermatitis and acute inflammation[1][2].
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Fepradinol | Fepradinol is an orally active nonsteroidal anti-inflammatory agent. Fepradinol inhibits the increase in vascular permeability induced by histamine, 5-hydroxytryptamine, and bradykinin, reduces exudate volume, prevents leukocyte migration, and suppresses acute inflammation models. Fepradinol also induces thrombotic vasculopathy with epidermal necrosis, without leukocytoclastic vasculitis; triggers occlusive contact dermatitis presenting as purpuric papulonecrotic lesions, and causes strongly positive patch test reactions. Fepradinol can be used in research related to occlusive contact dermatitis and acute inflammation. | |||||||||||||||||||||
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References
- [1]. Koch P, Bahmer F A. Erythema‐multiforme‐like, urticarial papular and plaque eruptions from bufexamac: report of 4 cases[J]. Contact Dermatitis, 1994, 31(2): 97-101.
- [2]. Masso JM, et al. Effects of fepradinol on rat acute models of vascular permeability and leucocyte migration. Agents and actions. 1994 Oct;42(3-4):118-22.
