38194-50-2
38194-50-2
Chemical Structure
Sulindac
Synonym(s): MK-231
- CAS No.: 38194-50-2
- Formula:C20H17FO3S
- Molecular Weight:356.41
IUPAC Name: (Z)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetic acid
InChIKey: MLKXDPUZXIRXEP-MFOYZWKCSA-N
SMILES: O=C(CC(C1=C2C=CC(F)=C1)=C(/C2=C/C3=CC=C(C=C3)S(C)=O)C)O
Biological Activity: Sulindac (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac also is an immunomodulatory agent. Sulindac can be used for the research of arthritis of the spine, gouty arthritis and kinds of cancer including colorectal cancer (CRC) and lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sulindac | 99.68% | Sulindac (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac also is an immunomodulatory agent. Sulindac can be used for the research of arthritis of the spine, gouty arthritis and kinds of cancer including colorectal cancer (CRC) and lung cancer. | ||||||||||||||||||||
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Sulindac (Standard) | ≥98% | Sulindac (Standard) is the analytical standard of Sulindac. This product is intended for research and analytical applications. Sulindac (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac also is an immunomodulatory agent. Sulindac can be used for the research of arthritis of the spine, gouty arthritis and kinds of cancer including colorectal cancer (CRC) and lung cancer. | ||||||||||||||||||||
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Sulindac-d3 | 99.38% | Sulindac-d3 is deuterium labeled Sulindac. Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.89
HY-B0008ASulindac sodium -
Similarity Score 0.85
HY-13633Exisulind -
Similarity Score 0.85
HY-B1787Sulindac sulfone -
Similarity Score 0.85
HY-B1786Sulindac sulfide -
Similarity Score 0.85
HY-B1786A(E/Z)-Sulindac sulfide -
Similarity Score 0.84
HY-153980K-80001 -
Similarity Score 0.81
HY-U00458K-80003 -
Similarity Score 0.80
HY-B1786SSulindac sulfide-d3 -
Similarity Score 0.79
HY-B1787SSulindac sulfone-d3 -
Explore the MedChemAI to find more analogs
References
- [1]. Byong-Ki Cha, et al. Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1. Oncotarget. 2016 Aug 30;7(35):57213-57227. [Content Brief]
- [2]. Bin Yi, et al. Sulindac Modulates the Response of Proficient MMR Colorectal Cancer to Anti-PD-L1 Immunotherapy. Mol Cancer Ther. 2021 Jul;20(7):1295-1304. [Content Brief]
