38214-71-0
38214-71-0
Chemical Structure
VRT-532
Synonym(s): CFpot-532
- CAS No.: 38214-71-0
- Formula:C16H14N2O
- Molecular Weight:250.30
IUPAC Name: 4-methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol
InChIKey: AQWKVJFRGORALM-UHFFFAOYSA-N
SMILES: OC(C=CC(C)=C1)=C1C2=NNC(C3=CC=CC=C3)=C2
Biological Activity: VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VRT-532 | 98.98% | VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis. | ||||||||||||||||||||
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References
- [1]. Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418(1):185-90. [Content Brief]
- [2]. Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282(46):33247-33251. [Content Brief]
Keywords
