38274-00-9
Chemical Structure
(+)-Epiloliolide
Synonym(s): Isololiolide
- CAS No.: 38274-00-9
- Formula:C11H16O3
- Molecular Weight:196.24
IUPAC Name: (6S,7aS)-6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one
InChIKey: XEVQXKKKAVVSMW-CPCISQLKSA-N
SMILES: C[C@@]12C(C(C)(C[C@@H](C1)O)C)=CC(O2)=O
Biological Activity: (+)-Epiloliolide is a megastigmane that can be isolated from Annona muricata[1]. (+)-epiloliolide increased the nuclear localization of p53[2]. (+)-Epiloliolide has anti-inflammatory effect through upregulating phosphorylation of the PKA/CREB pathway. (+)-Epiloliolide also effectively increases the proliferation and migration of human periodontal ligament cells by downregulating NLRP3 activated by PG-LPS[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(+)-Epiloliolide | 95.0% | (+)-Epiloliolide is a megastigmane that can be isolated from Annona muricata. (+)-epiloliolide increased the nuclear localization of p53. (+)-Epiloliolide has anti-inflammatory effect through upregulating phosphorylation of the PKA/CREB pathway. (+)-Epiloliolide also effectively increases the proliferation and migration of human periodontal ligament cells by downregulating NLRP3 activated by PG-LPS. | ||||||||||||||||||||
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References
- [1]. Matsushige A, et al. Three new megastigmanes from the leaves of Annona muricata. J Nat Med. 2012 Apr;66(2):284-91. [Content Brief]
- [2]. Chung Y, Jeong S, Lee IK, et al. Regulation of p53 Activity by (+)-Epiloliolide Isolated from Ulva lactuca. Mar Drugs. 2021;19(8):450. [Content Brief]
- [3]. Kim EN, Nabende WY, Jeong H, Hahn D, Jeong GS. The Marine-Derived Natural Product Epiloliolide Isolated from Sargassum horneri Regulates NLRP3 via PKA/CREB, Promoting Proliferation and Anti-Inflammatory Effects of Human Periodontal Ligament Cells. Mar Drugs. 2021;19(7):388. [Content Brief]
