38561-40-9
Chemical Structure
4-O-Methyl-ascochlorin
- CAS No.: 38561-40-9
- Formula:C24H31ClO4
- Molecular Weight:418.95
InChIKey: XUAAAHFMBMDZCQ-UMXIGZEWSA-N
SMILES: C[C@]1([C@H](C(CC[C@H]1C)=O)C)/C=C/C(C)=C/CC2=C(C(Cl)=C(C(C=O)=C2O)C)OC
Biological Activity: 4-O-Methyl-ascochlorin (Compound MAC) is a derivative of Ascochlorin (HY-101021). 4-O-Methyl-ascochlorin can selectively induce apoptosis of K562 leukemia cells, cause G1 phase arrest and downregulate c-Myc expression. 4-O-Methyl-ascochlorin can promote the phosphorylation of AMPK and inhibit the phosphorylation of mTOR and its target proteins, including p70S6 K and 4E-BP-1. 4-O-Methyl-ascochlorin can be used for research of leukemia[1].
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4-O-Methyl-ascochlorin | 4-O-Methyl-ascochlorin (Compound MAC) is a derivative of Ascochlorin (HY-101021). 4-O-Methyl-ascochlorin can selectively induce apoptosis of K562 leukemia cells, cause G1 phase arrest and downregulate c-Myc expression. 4-O-Methyl-ascochlorin can promote the phosphorylation of AMPK and inhibit the phosphorylation of mTOR and its target proteins, including p70S6 K and 4E-BP-1. 4-O-Methyl-ascochlorin can be used for research of leukemia. | |||||||||||||||||||||
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