38819-10-2
38819-10-2
Chemical Structure
9-β-D-Arabinofuranosylguanine
Synonym(s): AraG
- CAS. Nr.: 38819-10-2
- Formula:C10H13N5O5
- Molecular Weight:283.24
IUPAC Name: 2-amino-9-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
InChIKey: NYHBQMYGNKIUIF-FJFJXFQQSA-N
SMILES: O=C1C2=C(N=C(N)N1)N([C@H]3[C@@H](O)[C@H](O)[C@@H](CO)O3)C=N2
Biological Activity: 9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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9-β-D-Arabinofuranosylguanine | 99.77% | 9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease. | ||||||||||||||||||||
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References
- [1]. Shewach DS, et al. Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells. Cancer Res. 1989 Dec 1;49(23):6498-502. [Content Brief]
- [2]. Lotfi K, et al. Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity. Biochem Biophys Res Commun. 2002 May 24;293(5):1489-96. [Content Brief]
Keywords
