3922-74-5
3922-74-5
Chemical Structure
Diphenhydramine N-oxide
- CAS No.: 3922-74-5
- Formula:C17H21NO2
- Molecular Weight:271.35
IUPAC Name: 2-(benzhydryloxy)-N,N-dimethylethan-1-amine oxide
InChIKey: OEQNVWKWQPTBSC-UHFFFAOYSA-N
SMILES: C[N+](C)([O-])CCOC(C1=CC=CC=C1)C2=CC=CC=C2
Biological Activity: Diphenhydramine N-oxide is a metabolite of Diphenhydramine (HY-B0303). Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine can across the ovine blood-brain barrier (BBB) [1][2][3][4].
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Diphenhydramine N-oxide | Diphenhydramine N-oxide is a metabolite of Diphenhydramine (HY-B0303). Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine can across the ovine blood-brain barrier (BBB) . | |||||||||||||||||||||
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Diphenhydramine N-oxide-d6 | Diphenhydramine N-?Oxide-d6 is the deuterium labeled Diphenhydramine N-?Oxide. | |||||||||||||||||||||
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References
- [1]. Wong H, et al. Pharmacokinetics and renal excretion of diphenhydramine and its metabolites, diphenylmethoxyacetic acid and diphenhydramine-N-oxide, in developing lambs. J Pharm Sci. 2000 Oct;89(10):1362-70. [Content Brief]
- [2]. Jason P Berninger, et al. Effects of the antihistamine diphenhydramine on selected aquatic organisms. Environ Toxicol Chem. 2011 Sep;30(9):2065-72. [Content Brief]
- [3]. Föhr KJ, et al. Open channel block of NMDA receptors by diphenhydramine. Neuropharmacology. 2015 Dec;99:459-70. [Content Brief]
- [4]. Ehling S, et al. Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study. Vet Dermatol. 2019 Apr;30(2):91-e24. [Content Brief]
