393834-37-2
Chemical Structure
ATV399
- CAS No.: 393834-37-2
- Formula:C24H23N3O5S
- Molecular Weight:465.52
IUPAC Name: N-(4-((2-(pyridin-3-yl)piperidin-1-yl)sulfonyl)phenyl)benzo[d][1,3]dioxole-5-carboxamide
InChIKey: JLXWVIUZQVTKNB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCCCC2C=3C=NC=CC3)C4=CC=C5OCOC5=C4
Biological Activity: ATV399 is an inducible nitric oxide synthase (iNOS) inhibitor. ATV399 reduces NO production via allosteric inhibition of iNOS dimerization, thereby protecting rat pancreatic islet β-cells from cytokine-induced mitochondrial stress, endoplasmic reticulum stress, and apoptosis. ATV399 can be used in research related to type 1 diabetes[1].
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ATV399 | ATV399 is an inducible nitric oxide synthase (iNOS) inhibitor. ATV399 reduces NO production via allosteric inhibition of iNOS dimerization, thereby protecting rat pancreatic islet β-cells from cytokine-induced mitochondrial stress, endoplasmic reticulum stress, and apoptosis. ATV399 can be used in research related to type 1 diabetes. | |||||||||||||||||||||
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Keywords
