398507-81-8
398507-81-8
Chemical Structure
DNK-333
- CAS. Nr.: 398507-81-8
- Formula:C27H25Cl2F6N3O3
- Molecular Weight:624.40
IUPAC Name: N-((R,E)-1-(3,4-dichlorophenyl)-5-oxo-5-(((R)-2-oxoazepan-3-yl)amino)pent-3-en-2-yl)-N-methyl-3,5-bis(trifluoromethyl)benzamide
InChIKey: BHCJHYIMNHXLOM-WVDRJWPYSA-N
SMILES: O=C(N([C@H](CC1=CC(Cl)=C(Cl)C=C1)/C=C/C(N[C@H]2C(NCCCC2)=O)=O)C)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3
Biological Activity: DNK-333 is a potent and balanced dual NK1 and NK2 receptor antagonist with IC50 values of 4.8 nM and 5.5 nM, respectively. DNK-333 blocks the Neurokinin A (NKA) (HY-P0197)-induced bronchoconstriction in asthma[1].
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DNK-333 | DNK-333 is a potent and balanced dual NK1 and NK2 receptor antagonist with IC50 values of 4.8 nM and 5.5 nM, respectively. DNK-333 blocks the Neurokinin A (NKA) (HY-P0197)-induced bronchoconstriction in asthma. | |||||||||||||||||||||
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