402824-96-8
Chemical Structure
HCTZ-CH2-HCTZ
- CAS No.: 402824-96-8
- Formula:C15H16Cl2N6O8S4
- Molecular Weight:607.49
IUPAC Name: 6-chloro-4-(((6-chloro-1,1-dioxido-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine)-7-sulfonamido)methyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
InChIKey: ARZJHXODDVTRLY-UHFFFAOYSA-N
SMILES: O=S(N)(C1=C(Cl)C=C(N(CNS2(=O)=O)CNS(=O)(C3=C(Cl)C=C(NCNS4(=O)=O)C4=C3)=O)C2=C1)=O
Biological Activity: HCTZ-CH2-HCTZ is an isomer of HCTZ (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway[1][2].
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HCTZ-CH2-HCTZ | HCTZ-CH2-HCTZ is an isomer of HCTZ (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. | |||||||||||||||||||||
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- [1]. X Fang, et al. Purification and identification of an impurity in bulk hydrochlorothiazide. J Pharm Sci. 2001 Nov;90(11):1800-9. [Content Brief]
- [2]. Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8(6): p. 793-802. [Content Brief]
Keywords
