414905-09-2
Chemical Structure
Hdm2 E3 ligase inhibitor 1
- CAS No.: 414905-09-2
- Formula:C10H8F6N2O3S
- Molecular Weight:350.24
IUPAC Name: 3,3,3-trifluoro-N-(4-sulfamoylphenyl)-2-(trifluoromethyl)propanamide
InChIKey: SKFRRPUNXSXVKN-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(S(=O)(N)=O)C=C1)C(C(F)(F)F)C(F)(F)F
Biological Activity: Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor for Hdm2 (an E3 ubiquitin ligase)-mediated ubiquitination of the p53 protein with an IC50 of 12.7 μM. Hdm2 E3 ligase inhibitor 1 binds Hdm2, blocks Hdm2-catalyzed ubiquitin transfer from preligated Ub-Ubc4 to p53, inhibits p53 ubiquitination, stabilizes p53 protein in tumor cell and exhibits antitumor efficacy[1].
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Hdm2 E3 ligase inhibitor 1 | Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor for Hdm2 (an E3 ubiquitin ligase)-mediated ubiquitination of the p53 protein with an IC50 of 12.7 μM. Hdm2 E3 ligase inhibitor 1 binds Hdm2, blocks Hdm2-catalyzed ubiquitin transfer from preligated Ub-Ubc4 to p53, inhibits p53 ubiquitination, stabilizes p53 protein in tumor cell and exhibits antitumor efficacy. | |||||||||||||||||||||
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Keywords
