41692-24-4
41692-24-4
Chemical Structure
16,16-Dimethyl prostaglandin A1
Synonym(s): di-Me-PGA1
- CAS No.: 41692-24-4
- Formula:C22H36O4
- Molecular Weight:364.52
IUPAC Name: 7-((1R,2S)-2-((R,E)-3-hydroxy-4,4-dimethyloct-1-en-1-yl)-5-oxocyclopent-3-en-1-yl)heptanoic acid
InChIKey: CTQQHQGBBMYJPT-DZFVFWAGSA-N
SMILES: CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(C=C1)=O)CCCCCCC(O)=O
Biological Activity: 16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) is a prostaglandin analog that can inhibit DNA synthesis in Lewis lung carcinoma and B 16 amelanotic melanoma cells. 16,16-Dimethyl prostaglandin A1 also inhibits viral replication in both HSV and HIV-1 infection systems[1][2].
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16,16-Dimethyl prostaglandin A1 | 16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) is a prostaglandin analog that can inhibit DNA synthesis in Lewis lung carcinoma and B 16 amelanotic melanoma cells. 16,16-Dimethyl prostaglandin A1 also inhibits viral replication in both HSV and HIV-1 infection systems. | |||||||||||||||||||||
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References
- [1]. K V Honn, et al. Prostaglandin analogs as inhibitors of tumor cell DNA synthesis. Proc Soc Exp Biol Med. 1981 Apr;166(4):562-7. [Content Brief]
- [2]. M Hughes-Fulford, et al. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother. 1992 Oct;36(10):2253-8. [Content Brief]
