4209-30-7
4209-30-7
Chemical Structure
3'-NH2-ATP
- CAS. Nr.: 4209-30-7
- Formula:C10H17N6O12P3
- Molecular Weight:506.20
IUPAC Name: ((2S,3S,4R,5R)-3-amino-5-(6-amino-9H-purin-9-yl)-4-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: FVGNJWDZZCJDML-QYYRPYCUSA-N
SMILES: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](N)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3
Biological Activity: 3'-NH2-ATP, an ATP analogue, is a potent and competitive inhibitor of ATP, with a Ki of 2.3 μM. 3'-NH2-ATP can be used to synthesis of 3′-Amino-3′-deoxy transfer RNA by incorporation into the 3' terminus of tRNA-C-C[1][2].
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3'-NH2-ATP | 3'-NH2-ATP, an ATP analogue, is a potent and competitive inhibitor of ATP, with a Ki of 2.3 μM. 3'-NH2-ATP can be used to synthesis of 3′-Amino-3′-deoxy transfer RNA by incorporation into the 3' terminus of tRNA-C-C. | |||||||||||||||||||||
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References
- [1]. Armstrong VW, et, al. Interaction of substrate analogues with Escherichia coli DNA-dependent RNA polymerase. Eur J Biochem. 1976 Nov 1;70(1):33-8. [Content Brief]
- [2]. Fraser TH, et, al. Synthesis and aminoacylation of 3'-amino-3'-deoxy transfer RNA and its activity in ribosomal protein synthesis. Proc Natl Acad Sci U S A. 1973 Sep;70(9):2671-5. [Content Brief]
