42408-79-7
Chemical Structure
Pirandamine free base
- CAS No.: 42408-79-7
- Formula:C17H23NO
- Molecular Weight:257.38
IUPAC Name: N,N-dimethyl-2-(1-methyl-1,3,4,9-tetrahydroindeno[2,1-c]pyran-1-yl)ethan-1-amine
InChIKey: AMJPIGOYWBNJLP-UHFFFAOYSA-N
SMILES: O1CCC=2C=3C=CC=CC3CC2C1(C)CCN(C)C
Biological Activity: Pirandamine free base is a selective serotonin (5-HT) (HY-B1473A) uptake inhibitor with an IC50 of 250 nM. It exerts antidepressant-like effects by enhancing central serotonergic function, does not inhibit norepinephrine (HY-13715) uptake, and exhibits no central anticholinergic or monoamine oxidase inhibitory activity. Pirandamine free base is used in the study of depression[1][2][3][4].
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Pirandamine free base | Pirandamine free base is a selective serotonin (5-HT) (HY-B1473A) uptake inhibitor with an IC50 of 250 nM. It exerts antidepressant-like effects by enhancing central serotonergic function, does not inhibit norepinephrine (HY-13715) uptake, and exhibits no central anticholinergic or monoamine oxidase inhibitory activity. Pirandamine free base is used in the study of depression. | |||||||||||||||||||||
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References
- [1]. Lippmann W, et al. Effects of tandamine and pirandamine, selective blockers of biogenic amine uptake mechanisms, on gastric acid secretion and ulcer formation in the rat. Life Sci. 1977 Apr 15;20(8):1393-400.
- [2]. Pugsley T, et al. Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities. Psychopharmacology. 1976 May 05;47(1):33-41.
- [3]. Lippmann W, et al. Pirandamine, a relatively selective 5-hydroxytryptamine uptake inhibitor. Pharmacol Res Commun. 1976 Aug;8(4):387-405.
- [4]. Kopanski C, et al. Effects of long-term treatment of rats with antidepressants on adrenergic-receptor sensitivity in cerebral cortex: Structure activity study. Neurochemistry international. 1983;5(5):649-59. [Content Brief]
