428868-32-0
Chemical Structure
WAY 163909
- CAS No.: 428868-32-0
- Formula:C14H18N2
- Molecular Weight:214.31
IUPAC Name: (7bR,10aR)-1,2,3,4,7b,9,10,10a-octahydro-8H-cyclopenta[b][1,4]diazepino[6,7,1-hi]indole
InChIKey: XOSKJKGKWRIMGV-DGCLKSJQSA-N
SMILES: [H][C@@]12[C@@](N3CCNCC4=CC=CC2=C43)([H])CCC1
Biological Activity: WAY 163909 is an orally active, blood-brain barrier permeable 5-HT2C receptor-selective agonist. WAY 163909 exhibits an EC50 of 8 nM and a Ki of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia[1][2][3].
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WAY 163909 | WAY 163909 is an orally active, blood-brain barrier permeable 5-HT2C receptor-selective agonist. WAY 163909 exhibits an EC50 of 8 nM and a Ki of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia. | |||||||||||||||||||||
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- [1]. Dunlop J, et al. Pharmacological profile of the 5-HT(2C) receptor agonist WAY-163909; therapeutic potential in multiple indications. CNS Drug Rev. 2006;12(3-4):167-177. [Content Brief]
- [2]. Rosenzweig-Lipson S, et al. Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents. Psychopharmacology (Berl). 2007;192(2):159-170. [Content Brief]
- [3]. Murphy T J, Murnane K S. The serotonin 2C receptor agonist WAY-163909 attenuates ketamine-induced hypothermia in mice[J]. European journal of pharmacology, 2019, 842: 255-261.
Keywords
