4315-44-0
4315-44-0
Chemical Structure
NSC 57148
- CAS No.: 4315-44-0
- Formula:C28H30Cl2N6O2
- Molecular Weight:553.48
InChIKey: MVHALJRIOVBKOX-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(NC2=CC=C(C3=NC(CN3)C)C=C2)=O)C=C1)NC4=CC=C(C5=NC(CN5)C)C=C4.Cl.Cl
Biological Activity: NSC 57148 is a selective Grb7 SH2 domain antagonist with an IC50 value of 1.1 μM. NSC 57148 reduces cancer cell proliferation and migration. NSC 57148 is promising for research of Grb7-overexpressing malignancies such as breast and pancreatic cancers[1].
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NSC 57148 | NSC 57148 is a selective Grb7 SH2 domain antagonist with an IC50 value of 1.1 μM. NSC 57148 reduces cancer cell proliferation and migration. NSC 57148 is promising for research of Grb7-overexpressing malignancies such as breast and pancreatic cancers. | |||||||||||||||||||||
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