436866-52-3
Chemical Structure
TD114-2
- CAS No.: 436866-52-3
- Formula:C30H31N3O6
- Molecular Weight:529.58
IUPAC Name: (12E,32E)-22,25-dihydro-11H,21H,31H-6,9,12,15-tetraoxa-1,3(3,1)-diindola-2(3,4)-pyrrolacycloheptadecaphane-22,25-dione
InChIKey: GQZYZXZIMKZCBF-UHFFFAOYSA-N
SMILES: O=C(N1)C(C2=CN(CCOCCOCCOCCOCC3)C4=CC=CC=C24)=C(C1=O)C5=CN3C6=CC=CC=C56
Biological Activity: TD114-2 (cmpound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50=48 nM). TD114-2 is associated with the hydrogen bond formation of arginine 141 (ARG141) specific to GSK-3β, an amino acid that is often a negatively charged residue in other kinases, which determines the high selectivity of GSK-3β. TD114-2 can be used in the study of diabetes, neurodegenerative diseases and other diseases associated with GSK-3β[1].
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TD114-2 | TD114-2 (cmpound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50=48 nM). TD114-2 is associated with the hydrogen bond formation of arginine 141 (ARG141) specific to GSK-3β, an amino acid that is often a negatively charged residue in other kinases, which determines the high selectivity of GSK-3β. TD114-2 can be used in the study of diabetes, neurodegenerative diseases and other diseases associated with GSK-3β. | |||||||||||||||||||||
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Keywords
