441061-33-2
441061-33-2
Chemical Structure
Sinbaglustat
Synonym(s): ACT-519276; OGT2378
- CAS No.: 441061-33-2
- Formula:C11H23NO4
- Molecular Weight:233.30
IUPAC Name: (2S,3R,4R,5S)-2-(hydroxymethyl)-1-pentylpiperidine-3,4,5-triol
InChIKey: HCZQIIVHWYFIPW-UKKRHICBSA-N
SMILES: O[C@@H]1[C@H](CO)N(CCCCC)C[C@H](O)[C@H]1O
Biological Activity: Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions[1][2].
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Sinbaglustat | 99.83% | Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions. | ||||||||||||||||||||
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References
- [1]. Michael Weiss, et al. Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase. Cancer Res. 2003 Jul 1;63(13):3654-8. [Content Brief]
- [2]. Martine Gehin, et al. Assessment of Target Engagement in a First-in-Human Trial with Sinbaglustat, an Iminosugar to Treat Lysosomal Storage Disorders. Clin Transl Sci. 2021 Mar;14(2):558-567. [Content Brief]
