442548-99-4
442548-99-4
Chemical Structure
AZD1134
- CAS No.: 442548-99-4
- Formula:C28H32FN5O4
- Molecular Weight:521.58
SMILES: O=C(C1=CC(C2=C(O1)C(N3CCN(C)CC3)=CC(F)=C2)=O)NC4=CC=C(N5CCN(C(CC)=O)CC5)C=C4
Biological Activity: AZD1134 is an orally active, brain-penetrant and highly selective 5-HT1B receptor antagonist with IC50 values of 2.9 nM (human) and 0.108 nM (guinea pig), respectively. AZD1134 increases synaptic serotonin levels in guinea pigs. AZD1134 is promising for research of psychiatric disorders, such as depression and anxiety[1].
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AZD1134 | AZD1134 is an orally active, brain-penetrant and highly selective 5-HT1B receptor antagonist with IC50 values of 2.9 nM (human) and 0.108 nM (guinea pig), respectively. AZD1134 increases synaptic serotonin levels in guinea pigs. AZD1134 is promising for research of psychiatric disorders, such as depression and anxiety. | |||||||||||||||||||||
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References
Keywords
